No. 1 Alabama (5-0, 2-0 SEC) at No. 24 Texas A&M (3-2, 1-1)

3:30 p.m. EDT (CBS)

Line: Alabama by 17.

Series record: Alabama leads 9-2.

Alabama has risen to the top of the poll without facing a ranked team. Now, the Crimson Tide gets its first Top 25 test, on the road. The Aggies could make a huge statement with a win after a disappointing start that includes a 24-10 loss to No. 2 Clemson.

Florida State (3-2, 2-1 ACC) at No. 2 Clemson (5-0, 3-0)

2:30 p.m. (ABC)

Line: Clemson by 26 1/2.

Series record: Florida State leads 20-12.

Clemson is looking to extend its best-ever win streak to 21 straight games and move to 6-0 for the fifth consecutive season. Florida State is seeking a signature victory in coach Willie Taggart’s two seasons.

South Carolina (2-3, 1-2 SEC) at No. 3 Georgia (5-0, 2-0)

Noon (ESPN)

Line: Georgia by 24.

Series record: Georgia leads 51-18-2.

Georgia, favored by more than three touchdowns against a division rival for the second straight week, is trying to protect its SEC and national championship hopes. South Carolina is looking for a signature win under coach Will Muschamp. The Gamecocks also need to show improved ability to win away from home.

No. 7 Florida (6-0, 3-0 SEC) at No. 5 LSU (5-0, 1-0)

7 p.m. (ESPN)

Line: LSU by 13.

Series record: Florida leads 33-29-3.

Both teams are in position to contend for their respective division titles in the SEC and a College Football Playoff berth. While a first loss in a top-10 clash won’t necessarily eliminate either team from contention, it’ll leave little to no margin for error.

Michigan State (4-2, 2-1 Big Ten) at No. 8 Wisconsin (5-0, 2-0)

2:30 p.m. (BTN)

Line: Wisconsin by 10 1/2.

Series record: Michigan State leads 30-23.

After thumping Kent State, No. 8 Wisconsin looks to stay unbeaten when it steps back into Big Ten play and hosts Michigan State. The Badgers look to continue to build their resume as one of the top teams in the country.

Southern California (3-2) at No. 9 Notre Dame (4-1)

6:30 p.m. (NBC)

Line: Notre Dame by 10 1/2.

Series record: Notre Dame leads 48-37-5.

In the 91st renewal of what is called by many “the greatest intersectional rivalry in college football,” Clay Helton’s Trojans come off a bye week following a 28-14 loss at Washington. Brian Kelly’s Notre Dame squad followed a 23-17 loss at No. 3 Georgia with consecutive home victories.

No. 10 Penn State (5-0, 2-0 Big Ten) at No. 17 Iowa (4-1, 0-1)

6:30 p.m. (ABC)

Line: Penn State by 3 1/2.

Series record: Penn State leads 16-12.

The Nittany Lions expect to run into their first real challenge in Kinnick Stadium where the Hawkeyes will try to rebound from a close loss to Michigan in their Big Ten opener. Both teams are propelled by top 10 defenses.

Hawaii (4-1, 1-0 MWC) at No. 14 Boise State (5-0, 2-0)

9:15 p.m. (ESPN2)

Line: Boise State by 12 1/2.

Series record: Boise State leads 12-3.

It’s an early season Mountain West showdown as Hawaii gets a chance to prove its blowout win at Nevada two weeks ago was no fluke. The Warriors thumped Nevada 54-3, its most lopsided win since joining the Mountain West. A win on Boise’s blue turf would prove the Warriors are true contenders. The Broncos rolled at UNLV last Saturday as freshman QB Hank Bachmeier continued his impressive debut season.

No. 15 Utah (4-1, 1-1 Pac-12) at Oregon State (2-3, 1-1)

7 p.m. (Pac-12 Network)

Line: Utah by 14.

Series record: Oregon State leads 11-9-1.

Oregon State has been buoyed by a big win at UCLA last weekend. Quarterback Jake Luton threw a career-high five touchdowns and ran for another in the dominant 48-31 victory. It was the Beavers’ first Pac-12 victory since last October’s win at Colorado. Utah is coming off a bye, after rebounding from a loss to USC with a win at home over Washington State.

No. 16 Michigan (4-1, 2-1 Big Ten) at Illinois (2-3, 0-2)

Noon (ABC)

Line: Michigan by 22 1/2.

Series record: Michigan leads 70-23-2.

The Wolverines need to get and stay in a rhythm offensively to prepare for tougher tests coming up at No. 10 Penn State and against No. 9 Notre Dame, and No. 3 Ohio State at home. The Fighting Illini would love to end their 23-game losing streak to ranked teams.

Washington State (3-2, 0-2 Pac-12) at No. 18 Arizona State (5-1, 1-1)

2:30 p.m. (Pac-12 Network)

Line: Arizona State by 1 1/2.

Series record: Arizona State leads 17-5-2.

Arizona State is hoping to avoid the same fate it suffered after joining the AP Top 25 earlier this season. The Sun Devils moved into the rankings after beating Michigan State on the road, but lost the following week to Colorado. Washington State is looking for its first Pac-12 win.

Louisville (3-2, 1-1 ACC) at No. 19 Wake Forest (5-0, 1-0)

6:30 p.m. (ACC Network)

Line: Wake Forest by 6 1/2.

Series record: Louisville leads 4-2.

Wake Forest is playing its first game as a Top 25 team in 11 years and a victory will give the Demon Deacons their first 6-0 start since the 1944 team opened with seven straight wins. For the Cardinals, knocking off Wake Forest would count as their first big victory under new coach Scott Satterfield, a native North Carolinian.

Texas Tech (3-2, 1-1 Big 12) at No. 22 Baylor (5-0, 2-0)

3 p.m. (FS1)

Line: Baylor by 11 1/2.

Series record: Tied 38-38-1.

Baylor plays its first game as a ranked team under third-year coach Matt Rhule. Texas Tech last week knocked off then-No. 21 Oklahoma State, which had just gotten into the AP poll. The Bears have a seven-game winning streak that is the longest in the Big 12. A win keeps them tied atop the Big 12 standings with either No. 6 Oklahoma or No. 11 Texas.

No. 23 Memphis (5-0, 1-0 AAC) at Temple (4-1, 1-0)

Noon (ESPN2)

Line: Memphis by 5 1/2.

Series record: Tied 2-2.

Memphis is seeking to remain unbeaten and Temple is chasing its third straight victory. Both teams are unbeaten in American Athletic Conference play.

No. 25 Cincinnati (4-1, 1-0 AAC) at Houston (2-3, 0-1)

2:30 p.m. (ESPN2)

Line: Cincinnati by 7 1/2.

Series record: Houston leads 15-10.

The Bearcats got the inside track in the American Athletic East by upsetting then-No. 18 UCF 27-24 at Nippert Stadium, moving ahead of the two-time defending champs. They can’t afford a letdown a week later against a rebuilding team. The Cougars are looking to get settled under sophomore quarterback Clayton Tune, who made his first start of the season in a 45-26 win at North Texas.

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